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Symptoms and Treatment of Overdose: As Napa Extend Tablet is a sustained‐release formulation of paracetamol, absorption will be prolonged in overdose.
It is recommended that for the management of overdose, where Napa Extend Tablet is suspected, that an additional plasma paracetamol level be obtained 4-6 hours after the initial measurement either level is above or close to the treatment line on the paracetamol overdose nomogram, administration of antidote would be indicated.
Paracetamol overdose may cause liver failure which may require liver transplant or lead to death. Acute pancreatitis has been observed, usually with hepatic dysfunction and liver toxicity.
Immediate medical management is required in the event of an overdose, even if the symptoms of overdose are not present.
Administration of N-acetylcysteine may be required.
In cases of overdosage, methods of reducing absorption of ingested drug are important. Activated charcoal may reduce absorption of the medicine if given within one hour after oral ingestion. In patients who are not fully conscious or have impaired gag reflex, consideration should be given to administering activated charcoal via a nasogastric tube, once the airway is protected.
